Obor: Chemistry

Effective Strategies for the Production of Recombinant 2A Protease Enteroviruses (A71 and D68) for Subsequent Design of Protease Inhibitors

Enteroviruses (EVs) are single-stranded RNA viruses with positive polarity that cause widespread diseases with significant health and economic impacts, commonly affecting both young children and adults. They are the most frequent causative agents of viral respiratory and neurological infections. While they typically cause mild symptoms, they can also lead to severe issues such as acute…

A Look into the Heart of Affinity Biosensors: Custom Biochip Development

During this internship, the student will first become familiar with the fundamental principles of modern affinity optical and piezoelectric biosensors, which target the analysis of real, and therefore complex, biological samples, with a focus on public safety, clinical diagnostics, and food safety. The student will learn measurement techniques such as surface plasmon resonance (SPR) and…

Preparation and Optimization of Inorganic Crystals for the Detection of Ionizing Radiation

During the internship, the student will become familiar with the characterization and preparation of crystals for scintillation detectors of ionizing radiation. The crystals will be prepared using the modern micro-pulling-down method, which is currently available only at the Institute of Physics of the Czech Academy of Sciences. The influence of composition (stoichiometry) of gadolinium-gallium-aluminum garnet-based…

Detection of pathogens or antibodies against pathogens using the series of LSPR active nanocomposites

The main aim of this study is to develop a new detection system for selected bacteria and viruses, as well as their proteins and antibodies against them. The detection system is focused on the localized surface plasmon resonance (LSPR) where pathogen/protein/antibody attached to the LSPR sensors (containing metal nanoparticles) changes the optical and electrical characteristics.…

Utilization of immobilized factors for the differentiation of primary osteoblasts

Tissue cultures are a focus of research in various fields as biology, chemistry, immunology, and medicine. Typically, so-called immortalized cultures are used—these are cell cultures that can multiply indefinitely but are modified in certain ways and therefore differ from cells in actual tissues, such as various cancer cells. Recently, the use of so-called primary cells,…

Functional nanolayers for the real world

The student will become familiar with the procedures for the preparation, characterization, and application of functional nanolayers with so-called antifouling properties during their internship, which can have wide applications in the real world. They will learn methods such as post-modification of polymer layers to anchor bioreceptors to the surface, achieving targeted functional properties of the…

Unlocking the Potential of 2D Materials

Are you fascinated by the potential of emerging 2D materials and their diverse applications across various fields? Join us in exploring the extraordinary features of these materials and unlocking their full potential! At our lab, we focus on the tuning of the properties of 2D materials to optimize their performance for specific applications. One of…

Photoswitches – graphene functionalization using chiral organic molecules

In the current project, we are particularly interested in the covalent attachment of small organic molecules to 2D materials[i] and the linking of the latter via the former. While in most of our projects, the organic molecules used for surface modification are commercially available or readily available from such, some projects require more extensive synthetic efforts.…

Supercapacitors based on 2D material Ti3C2 MXene

This topic connected with energy storage. In this project, student will use the 2D Ti3C2 MXene flakes for fabrication of supercapacitor. MXene is a new 2D material and has unusual electronic, mechanical and optical properties. The student will know the principle of the supercapacitor as well as how to fabricate it. The main parameters of…