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Effective Strategies for the Production of Recombinant 2A Protease Enteroviruses (A71 and D68) for Subsequent Design of Protease Inhibitors

Enteroviruses (EVs) are single-stranded RNA viruses with positive polarity that cause widespread diseases with significant health and economic impacts, commonly affecting both young children and adults. They are the most frequent causative agents of viral respiratory and neurological infections. While they typically cause mild symptoms, they can also lead to severe issues such as acute…

Diagnostics of Reactive Plasma Using a Planar High-Frequency Probe During the Deposition of Layers with Antiviral Effects

As part of the internship, the student will be involved in the research of plasma deposition of crystalline CuFeO2 layers with antiviral effects. The deposition of CuFeO2 layers will be carried out using the method of reactive pulsed magnetron sputtering with an additional high-frequency inductively coupled plasma operating in resonance with the electron cyclotron wave.…

A Look into the Heart of Affinity Biosensors: Custom Biochip Development

During this internship, the student will first become familiar with the fundamental principles of modern affinity optical and piezoelectric biosensors, which target the analysis of real, and therefore complex, biological samples, with a focus on public safety, clinical diagnostics, and food safety. The student will learn measurement techniques such as surface plasmon resonance (SPR) and…

Preparation and Optimization of Inorganic Crystals for the Detection of Ionizing Radiation

During the internship, the student will become familiar with the characterization and preparation of crystals for scintillation detectors of ionizing radiation. The crystals will be prepared using the modern micro-pulling-down method, which is currently available only at the Institute of Physics of the Czech Academy of Sciences. The influence of composition (stoichiometry) of gadolinium-gallium-aluminum garnet-based…

Detection of pathogens or antibodies against pathogens using the series of LSPR active nanocomposites

The main aim of this study is to develop a new detection system for selected bacteria and viruses, as well as their proteins and antibodies against them. The detection system is focused on the localized surface plasmon resonance (LSPR) where pathogen/protein/antibody attached to the LSPR sensors (containing metal nanoparticles) changes the optical and electrical characteristics.…

Ph.D. thesis: Study of the influence of transients phenomena in piezoceramics in terms of fracture-mechanical response

The aim of this work is to determine and explain the change in mechanical behaviour due to transients with emphasis on the fracture mechanical response in selected lead-free piezioceramics. The main goal of the doctoral thesis will be to study the mechanical and fracture behaviour of piezoceramics (for example BTO, BTZC, etc.) during its transition…

Ph.D. thesis: Microscopic processes at the fatigue crack tip

Fatigue crack growth is a process that is described macroscopically by quantities such as the stress intensity factor, J-integral or plastic part of the J-integral. There are many models of crack propagation at the microscopic level that consider plastic deformation around the crack tip, but which differ in details. Advances in experimental methods allow more…

Ph.D. thesis: Development of hybrid composites compensating shrinkage at pyrolysis

This work aims to design and describe suitable methods of shrinkage compensation and/or control for the preparation of matrix composites and their effect on microstructural changes and fracture behaviour of hybrid composite materials containing such adapted matrix and ceramic fibres. The main goal of the doctoral thesis will be the design and characterization of hybrid…

Bulding ECG Databases

The task is to create a general ECG database – explore and choose the proper database platform (SQL/NoSQL), create the design as the diagram scheme, and finally implement the database on a server and fill it up with data.  Skupina Umělá inteligence a medicínské technologie, oddělení Medicínské signály/Group of Artificial Intelligence and Medical Technologies https://www.isibrno.cz/cs

Application of Molecular Dynamics in Materials Research

Molecular Dynamics (MD) is a computer simulation method that describes the motion of atoms and molecules. The trajectories of atoms and molecules are typically determined by numerically solving Newton’s equations of motion for a system of interacting particles, where the forces between particles and their potential energy are often calculated using interatomic potentials or molecular…