Obor: Biology

Junior Biophysicist

Cytoskeleton Remodeling as a Potential Regulator of Metabolic Rewiring in Liver Cancer Cells Emerging evidence has revealed that physical stimuli from the cellular microenvironment play a crucial role in transmitting mechanical signals that regulate key cellular functions such as proliferation, migration, and malignant transformation [1-3]. It is now clear that tumor cells are subjected to…

Effective Strategies for the Production of Recombinant 2A Protease Enteroviruses (A71 and D68) for Subsequent Design of Protease Inhibitors

Enteroviruses (EVs) are single-stranded RNA viruses with positive polarity that cause widespread diseases with significant health and economic impacts, commonly affecting both young children and adults. They are the most frequent causative agents of viral respiratory and neurological infections. While they typically cause mild symptoms, they can also lead to severe issues such as acute…

A Look into the Heart of Affinity Biosensors: Custom Biochip Development

During this internship, the student will first become familiar with the fundamental principles of modern affinity optical and piezoelectric biosensors, which target the analysis of real, and therefore complex, biological samples, with a focus on public safety, clinical diagnostics, and food safety. The student will learn measurement techniques such as surface plasmon resonance (SPR) and…

Detection of pathogens or antibodies against pathogens using the series of LSPR active nanocomposites

The main aim of this study is to develop a new detection system for selected bacteria and viruses, as well as their proteins and antibodies against them. The detection system is focused on the localized surface plasmon resonance (LSPR) where pathogen/protein/antibody attached to the LSPR sensors (containing metal nanoparticles) changes the optical and electrical characteristics.…

Utilization of immobilized factors for the differentiation of primary osteoblasts

Tissue cultures are a focus of research in various fields as biology, chemistry, immunology, and medicine. Typically, so-called immortalized cultures are used—these are cell cultures that can multiply indefinitely but are modified in certain ways and therefore differ from cells in actual tissues, such as various cancer cells. Recently, the use of so-called primary cells,…

Functional nanolayers for the real world

The student will become familiar with the procedures for the preparation, characterization, and application of functional nanolayers with so-called antifouling properties during their internship, which can have wide applications in the real world. They will learn methods such as post-modification of polymer layers to anchor bioreceptors to the surface, achieving targeted functional properties of the…

Segmentation of 2D biological objects

Segmentation of 2D biological objectsThe focus of the proposed work is the development of computer vision methods with an emphasis on object segmentation in 2D data. In collaboration with microbiologists, data will be analysed with specific tasks. The study will include the selection of appropriate metrics to compare the performance of different segmentation methods. Based…