Lokalita: České Budějovice

Effective strategies to produce recombinant 2Apro of enteroviruses (A71 and D68) for the subsequent design of protease inhibitors

Enteroviruses (EVs) are single-stranded RNA viruses with positive polarity whose members cause widespread human diseases with major health and economic impacts, commonly observed in young children and adults. They are the most common etiologic agents of viral respiratory and neurological infections, usually causing mild symptoms but capable of causing severe pathology, including acute asthma exacerbations,…

The use of immobilized factors for differentiation of primary osteoblasts

Tissue cultures are widespread in research in various biology, chemistry, immunology, and medicine fields. Usually, so-called immortalized cultures are used, i.e., cultures of cells that can multiply without limit, but are in some sense modified and therefore different from cells in real tissues – for example, various cancer cells. Recently, the use of so-called primary cells, i.e., cells that more…