Lokalita: České Budějovice

Effective Strategies for the Production of Recombinant 2A Protease Enteroviruses (A71 and D68) for Subsequent Design of Protease Inhibitors

Enteroviruses (EVs) are single-stranded RNA viruses with positive polarity that cause widespread diseases with significant health and economic impacts, commonly affecting both young children and adults. They are the most frequent causative agents of viral respiratory and neurological infections. While they typically cause mild symptoms, they can also lead to severe issues such as acute…

Detection of pathogens or antibodies against pathogens using the series of LSPR active nanocomposites

The main aim of this study is to develop a new detection system for selected bacteria and viruses, as well as their proteins and antibodies against them. The detection system is focused on the localized surface plasmon resonance (LSPR) where pathogen/protein/antibody attached to the LSPR sensors (containing metal nanoparticles) changes the optical and electrical characteristics.…

Utilization of immobilized factors for the differentiation of primary osteoblasts

Tissue cultures are a focus of research in various fields as biology, chemistry, immunology, and medicine. Typically, so-called immortalized cultures are used—these are cell cultures that can multiply indefinitely but are modified in certain ways and therefore differ from cells in actual tissues, such as various cancer cells. Recently, the use of so-called primary cells,…